THEME 1

Cheung A, Opzoomer J, Ilieva KM, Gazinska P, Hoffmann RM, Mirza H, et al. Anti-Folate Receptor Alpha-Directed Antibody Therapies Restrict the Growth of Triple-negative Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018;24:5098-111.      

Cook GJR, Azad GK, Taylor BP, Lee E, Morrison MS, Hughes S, et al. Imaging alphavbeta3 integrin expression in skeletal metastases with (99m)Tc-maraciclatide single-photon emission computed tomography: detection and therapy response assessment. European journal of nuclear medicine and molecular imaging. 2018;45:898-903.

Correa I, Ilieva KM, Crescioli S, Lombardi S, Figini M, Cheung A, et al. Evaluation of Antigen-Conjugated Fluorescent Beads to Identify Antigen-Specific B Cells. Frontiers in immunology. 2018;9:493.

Crescioli S, Chiaruttini G, Mele S, et al. Engineering and stable production of recombinant IgE for cancer immunotherapy and AllergoOncology. The Journal of allergy and clinical immunology. 2018;141:1519-23 e9.

Fazekas-Singer J, Singer J, Ilieva KM, Matz M, et al. AllergoOncology: Generating a canine anticancer IgE against the epidermal growth factor receptor. The Journal of allergy and clinical immunology. 2018;142:973-6 e11.

Hoffmann RM, Coumbe BGT, Josephs DH, Mele S, Ilieva et al. Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs). Oncoimmunology. 2018;7:e1395127.

Ilieva KM, Cheung A, Mele S, Chiaruttini G, Crescioli S, et al. Chondroitin Sulfate Proteoglycan 4 and Its Potential As an Antibody Immunotherapy Target across Different Tumor Types. Frontiers in immunology. 2017;8:1911.

Jensen-Jarolim E, Bax HJ, Bianchini R, Crescioli S, Daniels-Wells TR, Dombrowicz D, et al. AllergoOncology: Opposite outcomes of immune tolerance in allergy and cancer. Allergy. 2018;73:328-40.

Josephs DH, Nakamura M, Bax HJ, Dodev TS, Muirhead G, Saul L, et al. An immunologically relevant rodent model demonstrates safety of therapy using a tumour-specific IgE. Allergy. 2018.

Melandri D, Zlatareva I, Chaleil RAG, Dart RJ, Chancellor A, Nussbaumer O, et al. The gammadeltaTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness. Nature immunology. 2018.

Monypenny J, Milewicz H, Flores-Borja F, Weitsman G, Cheung A, et al. ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation. Cell reports. 2018;24:630-41.

Muliaditan T, Caron J, Okesola M, Opzoomer JW, Kosti P, Georgouli M, et al. Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis. Nature communications. 2018;9:2951.

Muliaditan T, Opzoomer JW, Caron J, Okesola M, Kosti P, Lall S, et al. Repurposing tin mesoporphyrin as an immune checkpoint inhibitor shows therapeutic efficacy in preclinical models of cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018.

Vantourout P, Laing A, Woodward MJ, Zlatareva I, Apolonia L, Jones AW, et al. Heteromeric interactions regulate butyrophilin (BTN) and BTN-like molecules governing gammadelta T cell biology. Proceedings of the National Academy of Sciences of the United States of America. 2018; 115:1039-44.

THEME 2

Ajina A, Maher J.  Strategies to address chimeric antigen receptor tonic signallingMolecular Cancer Therapeutics. 2018. 17(9):1795-1815.

Emami-Shahri N, Foster J, Kashani R, Gazinska P, Cook C, Sosabowski J*, Maher J*, Papa S*. Clinically compliant spatial and temporal imaging of Chimeric Antigen Receptor T-cellsNature Communications. 2018. 9(1):1081. (*co-senior authors).

Halim L, Ajina A, Maher J. Preclinical development of chimeric antigen receptor T-cell immunotherapy: implications of design for efficacy and safety. Best Practice & Research Clinical Haematology. 2018. 31(2)117-125.

Kosti P, Maher J, Arnold JN. Perspectives on Chimeric Antigen Receptor T-cell immunotherapy for solid tumorsFrontiers in Immunology. 2018. 9:1104.

Lu Z, Pham T, Rajkumar V, Yu Z, Pedley RB, Årstad E, Maher J, Yan R. A dual reporter iodinated labeling reagent for cancer positron emission tomography imaging and fluorescence-guided Surgery. Journal of Medicinal Chemistry. 2018.  61(4):1636-1645.

Mark A. Samaan, Polychronis Pavlidis, Sophie Papa, Nick Powell and Peter Inving. Gastrointestinal toxicity of immune checkpoint inhibitors: from mechanism to management. Nature Reviews Gastroenterology & Hepatology. March 2018

Man F, Lim L, Volpe A, Gabizon A, Shmeeda H, Draper B, Parente-Pereira AC, Maher J, Blower PJ, Fruhwirth GO, T M de Rosales R In vivo PET tracking of 89Zr-labeled V9V2 T-cells to mouse xenograft breast tumors activated with liposomal alendronateMolecular Therapy. 2018. Oct 16. pii: S1525-0016(18)30495-7

Mekkaoui, L., Parekh, F., Kotsopoulou, E., Darling, D., Dickson, G., Cheung, G. W., Chan, L., MacLellan-Gibson, K., Mattiuzzo, G., Farzaneh, F., Takeuchi, Y. & Pule, M Lentiviral vector purification using genetically encoded biotin mimic in packaging cell.  Molecular Therapy - Methods and Clinical Development. 2018. 

Shi Y, Dincheva L, Cook C, Bergamaschi C, Pavlakis GN, Farzaneh F, Gaensler K IL-15/IL-15Rα/CD80-expressing AML cell vaccines eradicate minimal residual disease in leukemic mice2018. Blood Advances. 

Wahba J, Natoli M, Whilding LM, Parente-Pereira AC, Youngrock J, Zona S, Lam EWF, Sith JR, Maher J, Ghaem-Maghami S (2018) Chemotherapy-induced apoptosis, autophagy and cell cycle arrest are key drivers of synergy in chemo-immunotherapy of epithelial ovarian cancer. Cancer Immunology Immunotherapy. 67(11): 1753-1765. 

THEME 3

Azad G, Siddique MM, Taylor B, Green A, O'Doherty J, Gariani J, Blake GM, Mansi J, Goh V, Cook GJR. Does measurement of (18)F-fluoride metabolic flux improve response assessment of breast cancer bone metastases compared with standardised uptake values in (18)F-fluoride PET/CT? J Nucl Med. 2018 Jul 24. pii: jnumed.118.208710. doi: 10.2967/jnumed.118.208710.  

Azad GK, Cousin F, Siddique M, Taylor B, Goh V, Cook GJR. Does Measurement of First-Order and Heterogeneity Parameters Improve Response Assessment of Bone Metastases in Breast Cancer Compared to SUV(max) in [(18)F]fluoride and (18)F]FDG PET? Mol Imaging Biol. 2018 Sep 24. doi: 10.1007/s11307-018-1262-3.

Ciccarelli FD Mutations differ in normal and cancer cells (2018) Nature News & Views commentary (in press)

Claus J, Patel GS, Autore F, Colomba A, Weitsman G, Soliman T, Roberts S, Zanetti-Domingues L, Hirsch M, George R, Ortiz-Zapater E, Barber PR, Vojnovic B, Yarden Y, Martin-Fernandez M, Cameron A, Fraternali F*, Ng T*, Parker PJ* (2018) Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface. eLIFE 7 *Senior Corresponding authors

Cook GJ, Goh V. Functional and Hybrid Imaging of Bone Metastases. J Bone Miner Res. 2018 Jun;33(6):961-972.

Cook GJR, Azad G, Owczarczyk K, Siddique M, Goh V. Challenges and Promises of PET Radiomics. Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):1083-1089. doi:10.1016/j.ijrobp.2017.12.268.

Gariani J, Westerland O, Natas S, Verma H, Cook G, Goh V. Comparison of whole body magnetic resonance imaging (WBMRI) to whole body computed tomography (WBCT) or (18)F-fluorodeoxyglucose positron emission tomography/CT ((18)F-FDG PET/CT) in patients with myeloma: Systematic review of diagnostic performance. Crit Rev Oncol Hematol. 2018 Apr;124:66-72.

Gawne P, Man F, Fonslet J, Radia R, Bordoloi J, Cleveland M, Jimenez-Royo P, Gabizon A, Blower PJ, Long NJ, Torres Martin de Rosales R. Manganese-52: applications in cell radiolabelling and liposomal nanomedicine PET imaging using oxine (8-hydroxyquinoline) as an ionophore. Dalton Trans 2018 ;47:in press. DOI: 10.1039/c8dt00100f.

Georgouli, M., Herraiz, C., Crosas-Molist, E., Fanshawe, B., Maiques, O.,  Perdrix, A., Pandya, P., Rodriguez-Hernandez, I., Ilieva, K.M., Cantelli, G., Karagiannis, P., Mele, S., Lam, H., Josephs, D.H., Matias-Guiu, X., Marti, R.M., Nestle, F.O., Orgaz, J.L., Malanchi, I., Fruhwirth, G.O., Karagiannis, S.N., and Sanz-Moreno, V. Regional activation of Myosin II in cancer cells drives tumour progression via NF-kB and a secretory cross-talk with the immune microenvironment. Cell.

Glynne-Jones R, Hall MR, Lopes A, Pearce S, Goh V, Bosompem S, Bridgewater J, Chau I, Wasan H, Moran B, Melcher L, West NP, Quirke P, Wong WL, Beare S, Hava N, Duggan M, Harrison M. BACCHUS: A randomised non-comparative phase II study ofneoadjuvant chemotherapy (NACT) in patients with locally advanced rectal cancer (LARC). Heliyon. 2018 Sep 22;4(9):e00804.

MS Hofman, P Eu, P Jackson, E Hong, D Binns, A Iravani, D Murphy, C Mitchell, S Siva, RJ Hicks, JD Young, PJ Blower, GE Mullen, Cold Kit for Prostate-Specific Membrane Antigen (PSMA) PET Imaging: Phase 1 Study of 68Ga-Tris(Hydroxypyridinone)-PSMA PET/CT in Patients with Prostate Cancer, J Nucl Med, 2018, 59:625-631

O'Doherty J, Jauregui-Osoro M, Brothwood T, Szyszko T, Marsden PK, O'DohertyMJ, Cook GJR, Blower PJ, Lewington V. (18)F-Tetrafluoroborate, a PET Probe for Imaging Sodium/Iodide Symporter Expression: Whole-Body Biodistribution, Safety, Radiation Dosimetry in Thyroid Cancer Patients. J Nucl Med. 2017 Oct;58(10):1666-1671.

Owusu M, Bannauer P, Ferreira da Silva J, Mourikis TP, Jones AJ, Májek P, Caldera M, Wiedner M, Lardeau C, André C., Mueller AC, Menche J,  Kubicek S, Ciccarelli FD and Loizou JI Mapping the human kinome in response to DNA damage Cell Reports

Prezzi D, Neji R, Kelly-Morland C, Verma H, OʼBrien T, Challacombe B, Fernando A, Chandra A, Sinkus R, Goh V. Characterization of Small Renal Tumors With Magnetic Resonance Elastography: A Feasibility Study. Invest Radiol. 2018 Jun;53(6):344-351.

Povoleri GAM, Nova-Lamperti E, Scotta C, Fanelli G, Chen YC, Becker PD, et al. Human retinoic acid-regulated CD161(+) regulatory T cells support wound repair in intestinal mucosa. Nature immunology. 2018.

Prezzi D, Mandegaran R, Gourtsoyianni S, Owczarczyk K, Gaya A, Glynne-Jones R, Goh V. The impact of MRI sequence on tumour staging and gross tumour volume delineation in squamous cell carcinoma of the anal canal. Eur Radiol. 2018. Apr;28(4):1512-1519. doi: 10.1007/s00330-017-5133-0.

Repana D*, Nulsen J*, Dressler L*, Bortolomeazzi M*, Kuppili Venkata S*, Tourna A, Yakovleva A, Palmieri T and Ciccarelli FD The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens. Genome Biology. 2018.  

Sah BR, Owczarczyk K, Siddique M, Cook GJR, Goh V. Radiomics in esophageal and gastric cancer. Abdom Radiol (NY). 2018 Aug 16. doi: 10.1007/s00261-018-1724-8.  

Sawas T, Killcoyne S, Iyer PG, Wang KK, Smyrk TC, Kisiel JB, Qin Y, Ahlquist DA, Rustgi AK, Costa RJ, Gerstung M, Fitzgerald RC, Katzka DA; OCCAMS Consortium. Identification of Prognostic Phenotypes of Esophageal Adenocarcinoma in Two Independent Cohorts. Gastroenterology. 2018.

Spencer, J., Montorsi, L., Siu J. Human intestinal lymphoid tissue in time and space Mucosal Immunology.

Szyszko TA, Cook GJR. PET/CT and PET/MRI in head and neck malignancy. Clin Radiol. 2018 Jan;73(1):60-69.

Westerland O, Sivarasan N, Natas S, Verma H, McElroy S, Winfield JM, Neji R, El-Najjar I, Kazmi M, Streetly M, Goh V. Added Value of Contrast-Enhanced T1-Weighted and Diffusion-Weighted Sequences for Characterization of Incidental Findings on Whole Body Magnetic Resonance Imaging in Plasma-Cell Disorders. Clin Lymphoma Myeloma Leuk. 2018 Aug 13. pii: S2152-2650(18)30619-0.

Withey SJ, Gariani J, Reddy K, Prezzi D, Kelly-Morland C, Ilyas S, Adam A, Goh V. Is there a role for perfusion imaging in assessing treatment response following ablative therapy of small renal masses-A systematic review. Eur J Radiol  2018 Jul 24;5:102-107. doi: 10.1016/j.ejro.2018.07.002.

Zhao Y, Uduman M, Siu JHY, Tull TJ, Sanderson JD, Wu YB, Zhou JQ, Petrov N, Ellis R, Todd K, Chavele KM, Guesdon W, Vossenkamper A, Jassem W, D'Cruz DP, Fear DJ, John S, Scheel-Toellner D, Hopkins C, Moreno E, Woodman NL, Ciccarelli F, Heck S, Kleinstein SH, Bemark M, Spencer J Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissues. Nature Communications. 2018 9:385