We use high throughput next-generation DNA sequencing to profile cancer patient and understand the dynamic interplay between the cancer genome and the tumour microenvironment. We complement the molecular profiling with RNA sequencing to compare the differential expression of genes during cancer progression and de-convolute the contribution of immune and stromal cell populations using gene signatures. We also develop computational methods to analyse and integrate these data and develop resources that researchers worldwide can use to understand more about the genomic modifications causing cancer. For example, we support the development of the Network of Cancer Genes, a catalogue of known and possible cancer genes in 119 cancer types.

The BRC genomics facility offers state of the art genomics facilities, including single cell library preparations, long read sequencing and bespoke protocols. The services are available to investigators at Guy’s and St Thomas’, King’s College London, as well as academic and commercial partners.

The Network of Cancer Genes (NCG) is a manually curated repository of 2,372 genes that are known or predicted to have a functional role in driving cancer. NCG annotates also several properties of these genes and collect available evidence of their alteration in cancer. Check the Genome Biology publication for the latest news on NCG.

Useful links:

Network Cancer genes

BRC genomics